Diva TV, which transmits "The Oprah Winfrey Show" in the UK, will broadcast the McCann's first US interview on Tuesday 5th May at 8pm. Viewers will see a digitally created photo that shows how Madeleine might look today, aged five.
The McCanns will talk to Oprah about the two-year hunt for their missing daughter, whilst the show's cameras go inside their home, spending the day with them and their 4-year-old twins, Sean and Amelie.
"The more people able to see Madeleine's image as she would look now the better," said Jon Farrar, Programming Director for NBC Universal Global Networks (UK), which owns Diva TV.
"By appearing on 'Oprah' the family can reach millions of people in America and, given the show is broadcast in 143 countries including here in the UK, target new audiences around the world. We hope it will lead to new and useful information."
NBC Universal hopes that airing the Oprah interview will prompt new information from the public. The company is working with the UK charity Missing People to facilitate sightings confidentially immediately following the transmission.
Jo Youle, Director of Services at the charity Missing People said, "We very much hope that, by airing Gerry and Kate McCann's interview with Oprah, anyone with that vital sighting will come forward in confidence on Freefone 0500-700-700."
The Oprah Winfrey Show: "Exclusive - The McCanns and the New Search for Madeleine" will be broadcast on Tuesday 5th May at 8pm. Diva TV is available on Sky channel 269 & Virgin channel 164.
Sightings of Madeleine can also be made online at http://www.missingpeople.org.uk/madeleinemccann